Description
Recombinant full-length human PRMT7 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The PRMT7 gene accession number is BC000146.
PRMT7 (protein arginine methyltransferase 7), an arginine methyltransferase that exhibited type III enzymatic activity, catalyzing the formation of omega-NG-monomethylarginine residues. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency